Bengaluru: The Indian Institute of Science (IISc) Wednesday said it has launched a “moonshot” project to develop brain co-processors that combine neuromorphic hardware with AI algorithms to enhance or restore brain function. The initiative is funded by the Pratiksha Trust, founded by Kris Gopalakrishnan and his wife Sudha.An MoU formalising the partnership was signed at IISc in the presence of Gopalakrishnan, Prof G Rangarajan, Director of IISc, and Prof B Gurumoorthy, chief executive, Foundation for Science, Innovation and Development (FSID), along with other faculty members and deans.“The project aims to develop both implantable and non-invasive brain co-processors capable of decoding neural activity from brain recordings, processing these signals using AI algorithms, and re-encoding them into the brain through neural stimulation or neurofeedback,” IISc said. The devices are expected to support cognitive rehabilitation, particularly for stroke survivors who have lost functions such as goal-directed reach and grasp.Gopalakrishnan said: “India is emerging as a global leader in neuroscience by uniting foundational research with clinical applications through collaborative, international partnerships. Supported significantly by the Pratiksha Trust, the Brain Co-Processors Moonshot Project accelerates the development of innovative medical technologies.”Ultimately, he said, these innovations aim to provide world-class transformative neurological treatments to the global population. The initiative builds on a pilot effort under IISc’s Brain, Computation and Data Science programme, a cross-departmental initiative involving more than 20 faculty members. That programme is also supported by the Pratiksha Trust.According to IISc, brain co-processors represent an emerging class of technologies designed to augment or restore the brain’s natural functions in real-world contexts. The current project seeks to build an AI-driven, closed-loop device that interfaces with different regions of the brain to restore coordinated movement.A key focus of the project is to develop indigenous capacity. The team plans to indigenise implant design, hardware systems and AI software stacks compatible with clinical infrastructure in low-resource settings. It also aims to create India-specific databases of stereo EEG and ECoG recordings, and to develop open-source AI tools, datasets and visualisation platforms as digital public goods.“In its first phase, the team will develop and validate a non-invasive neural co-processor to provide sensorimotor feedback for goal-directed reaching in stroke survivors. Parallel groundwork will be laid for an invasive implantable version,” IISc said.The second phase will focus on developing a minimally invasive embedded co-processor intended to restore sensorimotor coordination in individuals with chronic, multi-domain deficits following middle cerebral artery stroke.The IISc team will collaborate with medical professionals and researchers across India to clinically validate and deploy the devices in line with national and international standards, IIScs said, adding that feedback from neurologists, therapists, patients and caregivers will be incorporated throughout development. The institute will also work with research partners in India and abroad.Prof Rangarajan said the moonshot project brings together expertise across neuroscience, electrical engineering, bioelectronics and neuromorphic computing to address stroke rehabilitation.